A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.
Abdelnaby AE, Wang YH, Benson JC, Perez I, Shen M, McDermott M, Jishage M, Elhaw AT, Cruz-Rangel S, Courjaret R, Belkadi A, Yu F, Prado DS, Yuan S, Xin P, Straub AC, Schopfer FF, Hempel N, Hawse WF, Beck DB, Machaca K, Feske S, Trebak M
bioRxiv. 2026 Jul 13. doi: 10.64898/2026.07.10.737753.
Jul 13, 2026
Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome.
Son GY, Bomfim GHS, Xu F, Thomas SC, Rosenberg K, Kim T, Rice E, Budjav E, Jones R, Wang YH, Mitaishvili E, Feske S, Jones DR, Rosado-Olivieri E, Rothermel BA, Saxena D, Lacruz RS
Cell Rep. 2026 Jul 28;45(7):117619. doi: 10.1016/j.celrep.2026.117619.
Jul 28, 2026
CRAC channels as targets for immunotherapy.
Stauderman K, Hebbar S, Feske S
Curr Opin Immunol. 2026 Jun;100:102780. doi: 10.1016/j.coi.2026.102780.
Jun 2026
ZIP3 is essential for the encephalitogenic function of pTh17 cells by regulating intracellular zinc levels.
Drmić D, Wang L, Noyer L, Zhong L, Feske S
J Trace Elem Med Biol. 2026 Feb;93:127819. doi: 10.1016/j.jtemb.2026.127819.
Feb 2026
SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport.
Tao AY, Hu K, Noyer L, Zhong L, Li W, Wang L, Feske S
J Immunol. 2026 Mar 17;215(3). doi: 10.1093/jimmun/vkaf328.
Mar 17, 2026
Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy.
Santiago-Fernández O, Coletto L, Tasset I, Kaushik S, Concepcion AR, Qaisar R, Macho-González A, Lindenau K, Diaz A, Khawaja RR, Donega S, Banskota N, Ubaida-Mohien C, Pharaoh G, Ahn B, Hartnell LM, Ramírez-Pardo I, Chavda B, Gazteluiturri A, Kinter M, Ferrucci L, Reisz JA, D'Alessandro A, Van Remmen H, Muñoz-Cánoves P, Feske S, Cuervo AM
Nat Metab. 2025 Dec;7(12):2589-2611. doi: 10.1038/s42255-025-01412-9.
Dec 2025
ORAI1 mutation with mixed loss and gain of function properties causes immunodeficiency and HLH.
Noyer L, Yeung PS, Kahlfuss S, Li Lai C, McDermott M, Patel D, Yang J, Wang YH, Zhong L, Hsu P, Prakriya M, Feske S
J Hum Immun. 2025 Nov 03;1(4). doi: 10.70962/jhi.20250097.
Nov 3, 2025
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity.
Wang L, Noyer L, Jishage M, Wang YH, Tao AY, McDermott M, Gando I, Sidhu I, Hu K, Zhong L, Sun K, Drmic D, Kaufmann U, Feske S
Sci Immunol. 2025 Jun 20;10(108):eadq8860. doi: 10.1126/sciimmunol.adq8860.
Jun 20, 2025
Machine learning approach to single cell transcriptomic analysis of Sjogren's disease reveals altered activation states of B and T lymphocytes.
McDermott M, Li W, Wang YH, Chen AY, Lacruz R, Nadorp B, Feske S
J Autoimmun. 2025 Jun;154:103419. doi: 10.1016/j.jaut.2025.103419.
Jun 2025
STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TH1 differentiation.
Zhong L, Wang YH, Kahlfuss S, Jishage M, McDermott M, Yang J, Tao AY, Hu K, Noyer L, Raphael D, Patel D, Knight TE, Chitlur M, Machaca K, Feske S
Nat Immunol. 2025 Mar;26(3):484-496. doi: 10.1038/s41590-025-02089-8.
Mar 2025
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